Identification Of Protein Changes In Early-Onset Alzheimer's

With a lack of effective treatments for Alzheimer's, most of us would think long and hard about whether we wanted to know years in advance if we were genetically predisposed to develop the disease. For researchers, however, such knowledge is a window into Alzheimer's disease's evolution.

Understanding the biological changes that occur during the clinically "silent" stage - the years before symptoms appear - provides clues about the causes of the disease and may offer potential targets for drugs that will stop it from progressing.

Clues To Causes Of Nerve Cell Degeneration Provided By Spasticity Gene Finding

The discovery of a gene that causes a form of hereditary spastic paraplegia (HSP) may provide scientists with an important insight into what causes axons, the stems of our nerve cells, to degenerate in conditions such as multiple sclerosis.

In the Journal of Clinical Investigation, an international team of scientists led by Dr Evan Reid at the University of Cambridge, and Dr Stephan Zuchner from the University of Miami, report that mutations in the gene known as 'reticulon 2' on chromosome 19 cause a form of HSP, a condition characterised by progressive stiffness and contraction (spasticity) of the legs, caused by selective and specific degeneration of axons

You Don't Need To Stop Eating Out To Lose Weight

woman eating saladGoing out to eat has become a major part of our culture. Frequently eating out and consuming high-calorie foods in large portions at restaurants can contribute to excess calorie intake and weight gain. However, a study in the January/February 2012 issue of the Journal of Nutrition Education and Behavior demonstrates that individuals can eat out and still lose weight.


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