Circadian Rhythm Disruption Causes Neurodegeneration, Early Death

New research at Oregon State University provides evidence for the first time that disruption of circadian rhythms - the biological "clocks" found in many animals - can clearly cause accelerated neurodegeneration, loss of motor function and premature death.

The study was published in Neurobiology of Disease and done by researchers at OSU and Oregon Health and Science University. Prior to this, it wasn't clear which came first - whether the disruption of biological clock mechanisms was the cause or the result of neurodegeneration.

"In these experiments, we showed through both environmental and genetic approaches that disrupting the biological clock accelerated these health problems," said Kuntol Rakshit, an OSU graduate fellow.

Substance Abuse, Crime And Re-Arrest For Drug-Involved Parolees Reduced By Behavior Therapy

A study from Rhode Island Hospital has found that collaborative behavioral management may be effective in reducing substance abuse among convicted marijuana users who are paroled. The findings have important implications for the management of a substantial proportion of the U.S. community correctional population. The study is published in Addiction and is available online in advance of print.

Nanotechnology Researchers Develop New Strategy To Deliver Chemotherapy To Prostate Cancer Cells

Honing chemotherapy delivery to cancer cells is a challenge for many researchers. Getting the cancer cells to take the chemotherapy "bait" is a greater challenge. But perhaps such a challenge has not been met with greater success than by the nanotechnology research team of Omid Farokhzad, MD, Brigham and Women's Hospital (BWH) Department of Anesthesiology Perioperative and Pain Medicine and Research.

In their latest study with researchers from Massachusetts Institute of Technology (MIT) and Massachusetts General Hospital, the BWH team created a drug delivery system that is able to effectively deliver a tremendous amount of chemotherapeutic drugs to prostate cancer cells.

The study is electronically published in ACS Nano.


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