HIV / AIDS News

During Ovulation, Females May Be More Susceptible To Infection

New research published in the Journal of Leukocyte Biology suggests that high levels of estradiol present prior to ovulation decreases immune system effectiveness resulting in growth and promotion of infection

A new research report in the Journal of Leukocyte Biology suggests that a woman's ovarian cycle plays an important role in her susceptibility to infection. Specifically, researchers from Spain and Austria found that women are most susceptible to infection, such as Candida albicans or other sexually transmitted diseases, during ovulation than at any other time during the reproductive cycle.

Human Trials Initiated For New HIV Vaccine

In the first clinical trial of an injectable vaccine containing trimeric HIV envelope protein (gp140) relevant to the predominant strain of HIV in Africa, researchers from four UK academic centers (St George's University London, Imperial College, Hull York Medical School (HYMS; University of York) and the Medical Research Council Clinical Trial Unit) and from the Infectious Disease Research Institute (IDRI) have come together to evaluate whether the vaccine is safe for use in human volunteers. If the vaccine does prove to be safe, and induces appropriate immunity, it could be considered for further testing and eventually be evaluated for its effectiveness as a vaccine for protecting women against HIV infection in Sub-Saharan Africa.

Pathogenic Landscape Of HIV

In perhaps the most comprehensive survey of the inner workings of HIV, an international team of scientists led by researchers at the University of California, San Francisco has mapped every apparent physical interaction the virus makes with components of the human cells it infects work that may reveal new ways to design future HIV/AIDS drugs. Explored this week in back-to-back papers in the journal Nature, the survey reveals a pathogenic landscape in which HIV's handful of proteins makes hundreds of physical connections with human proteins and other components inside the cell.


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