Cardiovascular / Cardiology News

Discovery May Lead To New Approaches To Cancer, Neurodegeneration, Growth Defects And Diabetes

Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine say this process is even more complex than previously thought, with regulated genes actually relocated to other, more conducive places in the cell nucleus.

World's First Bedside Genetic Test Proves Effective

Tailored anti-platelet therapy, made possible through a novel point-of-care genetic test, optimizes treatment for patients who carry a common genetic variant, researchers at the University of Ottawa Heart Institute (UOHI) have found.

A UOHI clinical trial known as RAPID GENE studied 200 patients undergoing coronary stent implantation for acute coronary syndrome or stable angina. Use of a simple, saliva swab test performed by nurses at the bedside on half of the patients allowed doctors to almost instantly identify those with the genetic variant, known as CYP2C19*2, which puts them at risk of reacting poorly to standard anti-platelet drug therapy, and administer an alternative drug.

Diagnosis of Hypertrophic Cardiomyopathy, The Most Common Inherited Heart Disease, Not A Death Sentence

HypertrophicMost of the 600,000 Americans with hypertrophic cardiomyopathy (HCM) -- a genetic heart muscle disease -- can live normal life spans, according to the first science-based guideline for diagnosing and treating this disorder.

The joint recommendations of the American College of Cardiology Foundation and the American Heart Association are published online in Circulation: Journal of the American Heart Association and Journal of the American College of Cardiology.


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