Cancer / Oncology News

Potential Link Between Cancer And A Common Chemical In Consumer Products

A study led by a group of Nanyang Technological University (NTU) researchers has found that a chemical commonly used in consumer products can potentially cause cancer.

The chemical, Zinc Oxide, is used to absorb harmful ultra violet light. But when it is turned into nano-sized particles, they are able to enter human cells and may damage the user's DNA. This in turn activates a protein called p53, whose duty is to prevent damaged cells from multiplying and becoming cancerous. However, cells that lack p53 or do not produce enough functional p53 may instead develop into cancerous cells when they come into contact with Zinc Oxide nanoparticles.

In Cancer Survivors, Risk Of Second Cancer Mainly Confined To The Same Cancer Type As The First

Cancer survivors have more than double the risk of a second primary cancer of the same type, according to a study published in CMAJ (Canadian Medical Association Journal).

Danish researchers looked at data for the entire population of Denmark (7 493 705 people) from 1980 to 2007 to determine whether the risk of secondary cancer is linked to the type of cancer found in the first instance. About 10% - 765 255 people - had one or more diagnoses of primary cancer for a total of 843 118 diagnoses.

About 15% of cancer survivors worldwide are diagnosed with a second primary cancer.

An Unexpected Player In A Cancer Defense System

Researchers of the Swedish medical university Karolinska Institutet and the University of Cologne, Germany, have identified a new protein involved in a defense mechanism against cancer. The VCP/p97 complex is best known for its role in protein destruction and is involved in a type of familial dementia and ALS. In a novel study the researchers now describe how this complex also plays an important role in regulating the recruitment of the tumor suppressor protein 53BP1 to damaged DNA suggesting an important role for VCP/p97 in our body's defense against cancer.

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